Microarray Kits

Features:

East Asian Genomic Coverage

The array was built using an East Asian reference panel containing 9000 whole-genome sequences. It includes coverage of populations underrepresented in the 1000 Genomes Project.

Widespread Adoption

The infinium Asian Screening Array builds on the success of the Infinium Globral Screening Array, which was developed by a community of researchers, healthacare networks, direct to consumer companies, and service providers. Illumina screening arrays have been widely adopted, with over 20 million samples ordered by a global community of users.

Clinical Research and Disease-Related Content

The array provides a genomic tool for disease risk profiling, pharmacogenomics research, wellness and lifestyle reporting, and complex disease research. It includes updated markers from clinical databases, including ClinVar and PharmGKB.

Robust, Trusted Assay and Highly Scalable Workflow

The array supports genotyping and CNV calling for several sample types, including saliva, blood, buccal swabs, and formalin-fixed, paraffin-embedded (FFPE) samples. The Infinium platform is trusted for excellent data quality, with call rates > 99% and reproducibility > 99.9%. The high-throughput Infinium workflow maximizes sample processing while minimizing costs, instrumentation, lab space, and hands-on time

Features:

Comprehensive Genome-Wide Coverage

This kit includes content categories requested by methylation experts, such as: 

• CpG sites outside of CpG islands
• Non-CpG methylated sites identified in human stem cells (CHH sites)
• Differentially methylated sites identified in tumor versus normal
• FANTOM5 enhancers
• ENCODE open chromatin and enhancers
• DNase hypersensitive sites
• miRNA promoter regions

Integrated Analysis Software

MethylationEPIC data analysis is supported by the GenomeStudio Methylation Module. GenomeStudio Software enables researchers to effortlessly perform differential methylation analysis for small-scale studies. It features advanced visualization tools that enable researchers to view vast amount of data in a single graph, such as heat maps, scatter plots, and line plots. 

Content for the Infinium PsychArray-24 includes 265,000 proven tag SNPs found on the Infinium Core-24 BeadChip, 245,000 markers from the Infinium Exome-24 BeadChip, and 50,000 additional markers associated with common psychiatric disorders.

These additional SNPs include genetic variants associated with the research of common psychiatric conditions such as schizophrenia, bipolar disorder, autism spectrum disorder, attention deficit hyperactivity disorder, major depressive disorder, obsessive compulsive disorder, anorexia, and Tourette’s syndrome.

For greater flexibility, the Infinium PsychArray-24+ version of the BeadChip can be customized to include up to 60,000 additional markers.

This BeadChip was developed by Illumina in collaboration with the USDA-ARS, University of Missouri, and the University of Alberta. More than 22,000 SNP probes target novel SNP loci that were discovered by Illumina sequencing of 3 pooled populations of economically important beef and dairy cattle.

Additional content is derived from publicly available sources such as the bovine reference genome, Btau, and the Bovine HapMap Consortium data set. All SNP probes have been validated in 18 common beef and dairy breeds. This product targets evenly distributed SNPs that are polymorphic across the breeds tested and provides a median spacing of 37.4 kb.

This array offers:

• Excellent call rates and accuracy- 99% mean call rate and > 99.9% reproducibility
• High-value content with comprehensive coverage- Evenly distributed polymorphic SNPs with 1cM mean spacing
• High-throughput and flexible format- Up to 24 samples can be genotyped in parallel

The genome-wide content was selected for high imputation accuracy at minor allele frequencies of >1% across all 26 1000 Genomes Project populations. The clinical research content includes variants with established disease associations, relevant pharmacogenomics markers, and curated exonic content based on ClinVar, NHGRI, PharmGKB, and ExAC databases. Quality control content enables sample identification and tracking for large-scale genomics and screening applications.

Widespread Adoption

With over 5.5 million samples worth of BeadChips sold before commercial launch, the array’s global adoption provides a network of human disease researchers, healthcare networks, consumer genomics companies, and genomic service providers to help power discovery.

Broad Clinical Research Applications

The array provides a genomic tool for clinical research applications including disease risk profiling studies, pharmacogenomics research, wellness characterization, and complex disease discovery.

In March 2018, Illumina released a free update enhancing coverage in pharmacogenomics, ClinVar, HLA, and ACMG variants.

Robust Assay and High-Throughput Workflow

The array supports genotyping and CNV calling for sample types including saliva, blood, and buccal swabs. The format also enables processing of thousands of samples per week with a 3-day workflow for population-scale studies.

With high data quality and cutting edge content, including full support of copy number variation (CNV) applications, this powerful genotyping tool allows you to make meaningful discoveries.

Optimized tag SNP content from all three HapMap phases has been strategically selected to capture the greatest amount of common variation and drive the discovery of novel associations with traits and diseases. For greater flexibility, the Infinium OmniExpress-24+ version of the BeadChip can be customized to include up to 30,000 additional markers. 

Using the proven iScan system, this four-sample BeadChip offers high-throughput sample processing, with optimized content for whole-genome genotyping and copy number variation (CNV) studies.