Sciex

The company’s global leadership and world-class service & support in the mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery & development, food & environmental testing, forensics and clinical research. With over 40 years of proven innovation, AB SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis.

The TripleTOF® 6600 extends the power and features of AB SCIEX TripleTOF® technology, delivering high performance and reproducibility that can detect virtually every peptide in every run when executing SWATH™ Acquisition 2.0.

The TripleTOF® 6600 offers:

  • Broader linear dynamic range: greater than 5 orders
  • Wider Q1 mass range: isolation for ions up to 2250 m/z
  • Enhanced mass accuracy stability
  • Higher quality MS/MS with superior mass resolution and speed:
    – 35,000 TOF MS mode- 20,000 high-sensitivity MS/MS mode
    – 30,000 high-resolution TOF MS/MS mode
    – Up to 100 MS/MS per second

The TripleTOF® 6600 maximizes productivity with its real-time management of MS/MS acquisition time, based on the intensity of selected precursors

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The SCIEX QTRAP® 6500 LC/MS/MS System with revolutionary, new, multi-component IonDrive™ Technology merges highly-evolved sensitivity with renowned performance. Adopting an intelligent approach to increasing the limits of quantitation, the patented IonDrive™ Technology introduces a series of advancements that increase the quantity of ions produced while enhancing the way ions are transmitted and detected.

QTRAP® 6500 LC/MS/MS System advantages:

  • Signal-to-noise and LOQ improvement of up to five-fold over the widest range of compounds and flow rates
  • Twenty-fold increase in detector dynamic range
  • No compromise in mass range with a 2000 m/z upper mass limit
  • Scan speeds of up to 20,000 Da/second for optimized UHPLC strategies
  • Increased throughput with polarity switching speeds of 20 msec
  • Compatibility with SelexION™ Differential Ion Mobility Technology

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The SCIEX Triple Quad™ 6500 System with revolutionary, new, multi-component IonDrive™ Technology merges highly-evolved sensitivity with renowned performance. Adopting an intelligent approach to increasing the limits of quantitation, the patented IonDrive™ Technology introduces a series of advancements that increases the quantity of ions produced while enhancing the way ions are transmitted and detected. The results speak for themselves.

  • Signal-to-noise and LOQ improvement of up to five-fold over the widest range of compounds and flow rate
  • Twenty-fold increase in detector dynamic range
  • Uncompromising mass range with a 2000 m/z upper mass limit
  • Scan speeds of up to 12,000 Da/second for optimized UHPLC strategies
  • Increased throughput with polarity switching speeds of 20 msec
  • Compatibility with SelexION™ Differential Ion Mobility Technology

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The iTRAQ Reagents are the first set of multiplexed, amine-specific, stable-isotope reagents that can label all peptides in up to eight different biological samples enabling simultaneous identification and quantitation, both relative and absolute, while retaining important PTM information.

  • Simultaneously identify and quantify proteins from multiple samples
  • Expands protein and proteome coverage by labeling all peptides, including those with post-translational modifications (PTMs)
  • Increases confidence in identification and quantitation from MS/MS spectra by tagging multiple peptides per protein
  • Increases throughput and confidence in results for protein biomarker discovery studies
  • Offers a simple workflow without sample fractionation for reduced-complexity samples, such as affinity pull-downs
  • Provides the flexibility to multiplex up to eight different biological samples simultaneously in a single experiment
  • Fully supported by ProteinPilot Software on all SCIEX proteomics LC/MS/MS platforms

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