ArcherDX addresses the bottleneck associated with using next-generation sequencing in translational research by offering a robust platform for targeted sequencing applications. By combining proprietary Anchored Multiplexed PCR (AMR) chemistry and easy-to-use, lyophilized reagents, ArcherDX technology generates highly enriched sequencing libraries to detect gene fusions, SNPs, indels and CNVs. Complemented by the Archer suite of bioinformatics software and readily accessible reports, ArcherDX technology dramatically enhances complex mutation identification and discovery.
Solid Tumor Blood CancerSarcomaNTRK fusionProductsWorkflow

Solid Tumor Assay

Archer® Solid Tumor assay provide a targeted sequencing approach to detect various driver mutation types in solid tumors. This approach combines FusionPlex®, VariantPlex® and Reveal-ctDNA™ kits to characterize gene fusions, CNVs and other variants from a single, low-input FFPE sample and liquid biopsy.

Key features:

  • Unified workflow- All Archer kits are powered by AMP™ chemistry and thus follow the same workflow for maximum efficiency
  • Superior mutation profiling- fusions, CNVs, SNVs, indels and expression levels
  • Variable input type- Kits are optimized for low-input FFPE and liquid biopsies, so both the tumor and ctDNA can be sequenced
  • Confident mutation calling- Powerful bioinformatics combined with orthogonal mutation verification ensure that you sleep well at night

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Blood Cancer Assay

Archer® Blood Cancer assays detect various driver mutation types in myeloid and lymphoid malignancies by next-generation sequencing (NGS). This approach combines FusionPlex® and VariantPlex® kits to characterize gene fusions, CNVs and other variants from a single sample

Key features:

  • Unified workflow- All Archer kits are powered by AMP™ chemistry and thus follow the same workflow for maximum efficiency
  • Superior mutation profiling- fusions, CNVs, SNVs, indels and expression levels
  • Variable input type- Kits are optimized for low-input FFPE and liquid biopsies, so both the tumor and ctDNA can be sequenced
  • Confident mutation calling- Powerful bioinformatics combined with orthogonal mutation verification ensure that you sleep well at night

Read more HERE

Sarcoma Kit

Archer® FusionPlex® Sarcoma kit is a targeted sequencing assay to simultaneously detect and identify fusions of 26 genes associated with soft tissue cancers. Using Archer’s proprietary Anchored Multiplex PCR (AMP™)-based enrichment, fusions of all genes in this kit can be identified in a single sequencing assay, even without prior knowledge of fusion partners or breakpoints.

Key features:

  • Comprehensive- identify multiple sarcoma-related fusions in a single assay
  • Detailed- characterize fusion partners at single-nucleotide resolution
  • Innovative- identify novel fusion partners and fusion breakpoits
  • Streamlined- reduce turn-around time and eliminate reflex testing

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NTRK Fusions

NTRK fusions are critical events in cancer biology notoriously difficult-to-detect known and unknown fusion partners.

Archer® FusionPlex® NGS assays provide sensitive NTRK fusion detection without prior knowledge of breakpoints or fusion partners.

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Products

VariantPlex®/DNA Assay

Archer® VariantPlex® NGS assays combine patented enrichment chemistry, an easy workflow and powerful bioinformatics to generate target-enriched libraries from DNA to confidently detect CNVs, SNVs and indels by NGS.

  • Myeloid kit
  • Core Myeloid kit
  • Solid Tumor kit
  • Comprehensive Thyroid & Lung (CTL)
  • CFTR53
  • BRCA1/2± PALB2
  • AML Focus
  • Solid Tumor Focus
  • p53
  • Custom Panel

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FusionPlex®/RNA Assay

Archer® FusionPlex® assays generate target-enriched cDNA libraries from RNA to characterize gene fusions, SNVs, indels and detect expression levels by next-generation sequencing (NGS).

  • Solid Tumor
  • Comprehensive Thyroid & Lung (CTL)
  • Sarcoma
  • Oncology Research
  • ALK RET ROS1 v2
  • Lung
  • Acute Lymphoblastic Leukemia (ALL)
  • Myeloid
  • Lymphoma
  • Pan Heme
  • Custom Panel

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Reveal ctDNA

NGS kits for liquid biopsy samples

The Archer® Reveal ctDNA™ 28 Kit for Illumina® is an advanced and user-friendly solution for targeted next generation sequencing (NGS) of circulating cell-free tumor DNA (ccfDNA/cfDNA/ctDNA) from 28 genes commonly found mutated in solid tumor type cancers.

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Immunoverse

Archer® Immunoverse™ kits are targeted NGS assays to characterize the human immune repertoire from RNA input. Powered by Anchored Multiplex PCR (AMP™), the lyophilized kits uniquely tag and amplify V(D)J rearrangements for sequencing on Illumina® platforms. Sequenced libraries are analyzed using the Immune Repertoire pipeline in Archer Analysis—a powerful and transparent tool for clonotype identification and frequency reporting.

Read more HERE

ArcherDx Workflow